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課程名稱 |
生物資訊學
BIOINFORMATICS |
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開課學期 |
99-1 |
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授課對象 |
生命科學院 基因體與系統生物學學位學程 |
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授課教師 |
林恩仲 |
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課號 |
AniSci7025 |
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課程識別碼 |
626 M1610 |
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班次 |
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學分 |
3 |
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全/半年 |
半年 |
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必/選修 |
選修 |
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上課時間 |
星期三2,3,4(9:10~12:10) |
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上課地點 |
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備註 |
上課教室:生物產業自動化教學研究中心
總人數上限：20人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/991bioinfomatics |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
The basic training of bioinformatics principles and tools is going to be mentioned in this course, including sequence alignment, database searching, phylogenetic analysis, gene and promoter prediction, protein/RNA structure as well as function and pathway in systems biology. |
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課程目標 |
This course is designed to guide graduate students applying different bioinformatic tools to launch genomic, proteomic, and phylogenetic study. With abundant information from those public databases, students will learn how to integrate and interpret gene/gene products and related functions in gene level as well as in genomic level. |
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課程要求 |
genetics or molecular genetics/biology (or courses equivalent to) |
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預期每週課後學習時數 |
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Office Hours |
每週二 10:00~12:00 備註： 10:00am~12:00pm Tuesday (林恩仲) |
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指定閱讀 |
Zvelebil, M. and J. O. Baum. 2008. Understanding Bioinformatics. Published by: Garland Science, Taylor & Francis Group, LLC. |
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參考書目 |
Mount, D. W. 2004. Bioinformatics: Sequence and Genome Analysis. 2nd Ed. Published by: Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, U.S.A.
Neil C. Jones and Pavel A. Pevzner. 2004. An Introduction to Bioinformatics Algorithms (Computational Molecular Biology). Published by: The MIT Press. |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
期中考 |
30% |
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2. |
期末考 |
40% |
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3. |
作業及上課參與 |
30% |
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週次 |
日期 |
單元主題 |
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第1週 |
9/15 |
Basic of DNA, RNA and Protein (Ch.1 & 2) |
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第2週 |
9/22 |
中秋節放假一天(the Moon Festival, one day off) |
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第3週 |
9/29 |
Basic of Database (Ch.3) |
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第4週 |
10/06 |
Pairwise Sequence Alignment (Part of Ch.4 & 5: 4.1~4.4 + p.87~89 of 4.5; 5.1~5.2) |
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第5週 |
10/13 |
Database Searching (Part of Ch.4 & 5: 4.6~4.10; 5.3~5.5) |
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第6週 |
10/20 |
Patterns, Profiles, and Multiple Alignment (Ch. 6 + p.89~93 of 4.5) |
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第7週 |
10/27 |
Phylogenetic Tree Reconstruction (Ch.7) |
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第8週 |
11/03 |
Generating and Evaluating Phylogenetic Tree (Ch.8) |
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第9週 |
11/10 |
期中考(Midterm exam) |
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第10週 |
11/17 |
Gene Prediction (Ch.9) |
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第11週 |
11/24 |
Prediction of Promoter Region (Ch.9) |
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第12週 |
12/01 |
Prediction of Gene Function |
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第13週 |
12/08 |
Prediction of Secondary Structure: Protein (part of Ch.11 & 12) |
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第14週 |
12/15 |
Prediction of Secondary Structure: RNA (Part of Ch.11) |
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第15週 |
12/22 |
Modeling Protein Structure (Ch.13) |
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第16週 |
12/29 |
Structure Comparison (Ch.14) |
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第17週 |
1/05 |
Systems Biology (Ch.17) |
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第18週 |
1/12 |
期末考(Final exam) |
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